AI & Reproductive Medicine

人工智能
与生殖医学前沿
AI
Frontiers in Reproductive Medicine

依托 华西第二医院天府锦城实验室 双重国家级平台
致力于生育力调控和生殖相关疾病研究
Based at the dual national platforms of West China Second Hospital and Tianfu Jincheng Laboratory.
Dedicated to decoding oocyte aging mechanisms and clinical translation of fertility preservation strategies.

查看最新成果Latest Publications
张曜耀教授

张曜耀Yaoyao Zhang 教授Professor

博士生导师 | 主任医师 Ph.D. Supervisor | Chief Physician

课题组长简介Principal Investigator

青年长江学者,华西第二医院生殖医学科主任医师。博士毕业于北京大学,以第一/通讯作者在 Nature Communications, Molecular Cell, Signal Transduction and Targeted Therapy (STTT) 等国际顶级期刊发表多篇高水平论文。主持国家自然科学基金面上项目、青年项目及中国博士后科学基金特别资助等多项国家级课题。

获四川省科技进步二等奖,四川省医学科技二等奖,中华医学会生殖医学分会、中国医师协会生殖医学专委会、中国妇幼保健学会、北京大学妇产科学系、四川省医学会优秀成果奖等荣誉。受邀在欧洲生殖年会(ESHRE),美国生殖年会(ASRM),国际生育联盟大会(IFFS),亚太生殖年会(ASPIRE)、国际定量生物学大会、中华医学会生殖医学分会、中国医师协会生殖医学分会、中国细胞生物学会等国际国内学术大会做特邀报告。

Young Changjiang Scholar, Chief Physician of Reproductive Medicine at West China Second University Hospital. Graduated with a Ph.D. from Peking University under the mentorship of Academician Jie Qiao.

He has published academic papers in leading international journals such as Nature Communications, Molecular Cell, Signal Transduction & Targeted Therapy (STTT), and European Journal of Cancer as first or corresponding author. His research findings have been cited by top journals like Nature, Cell, and Science. He leads multiple national-level projects, including grants from the National Natural Science Foundation of China.

He has received the Sichuan Science and Technology Progress Award (2nd Prize) and outstanding achievement awards from CSRM, CMDA, CMCHA, and Peking University. He has been invited to give special reports at international and domestic academic conferences such as ESHRE, ASRM, IFFS, ASPIRE, CSRM, CMDA, and CSCB.

四川省“特聘专家”Distinguished Expert of Sichuan Province 四川大学“双百人才计划”Sichuan University "Double Hundred Talents Plan" 临床指南编写专家Guideline Expert

核心研究方向 Core Research Areas

结合临床痛点,聚焦三大前沿领域 Focusing on three cutting-edge fields to address clinical challenges

卵母细胞衰老机制Oocyte Aging Mechanisms

解析高龄导致卵子质量下降的线粒体代谢与非整倍体发生机制。 Unraveling mitochondrial metabolism and aneuploidy mechanisms in age-related oocyte quality decline.

生育力保存新策略Novel Strategies for Fertility Preservation

开发针对放化疗损伤的卵巢保护药物及新型冷冻复苏技术。 Developing novel ovarian protective drugs and cryopreservation techniques against chemotherapy damage.

单细胞多组学分析Single-Cell Multi-omics Analysis

绘制生殖系统发育时空图谱,挖掘疾病潜在治疗靶点。 Mapping spatiotemporal atlases of reproductive system development and discovering therapeutic targets.

INFRASTRUCTURE

科研平台 Research Facilities

依托华西二院天府锦城实验室(前沿医学中心)双重国家级平台,实现了从临床样本到基础研究,再回归临床转化的全链条闭环。 Based on the dual national platforms of West China Second Hospital and Tianfu Jincheng Laboratory, we have achieved a full-chain closed loop from clinical samples to basic research and back to clinical translation.

WEST CHINA 2ND HOSPITAL

华西第二医院West China Second Hospital

国家妇产疾病临床医学研究中心,提供顶尖的临床资源支持。 National Clinical Research Center for Obstetrics and Gynecology.

国家级临床中心National Clinical Center

依托国家妇产疾病临床医学研究中心,拥有全国领先的妇产科临床诊疗规模与疑难重症救治能力。 Relying on the National Clinical Research Center, leading the country in clinical diagnosis and treatment scale.

千万级生物样本库Massive Biobank

建立了标准化的生殖医学专病样本库,涵盖卵泡液、颗粒细胞、胚胎培养液等珍贵临床样本,为科研提供坚实基础。 Established a standardized biobank for reproductive medicine, covering follicular fluid, granulosa cells, etc.

临床转化试验基地Clinical Trial Base

拥有完善的GCP管理体系,支持开展前瞻性随机对照试验(RCT),加速基础研究成果向临床应用转化。 Comprehensive GCP management system supporting prospective RCTs to accelerate the translation of basic research.

前沿组学技术平台Advanced Omics Platform

配备 10x Genomics 单细胞测序系统、空间转录组测序平台。具备从微量样本建库到生信深度挖掘的独立分析能力。 Equipped with 10x Genomics single-cell sequencing systems and spatial transcriptomics platforms.

分子生物学中心Molecular Biology Center

拥有完善的分子生物学实验设备,支持基因编辑、蛋白互作、表观遗传修饰等深层次机制研究。 Comprehensive molecular biology equipment supporting gene editing, protein interaction, and epigenetic studies.

超高分辨显微成像中心Super-Resolution Imaging Center

拥有 Leica SP8 激光共聚焦显微镜、活细胞工作站、显微操作系统及双光子显微镜。 Features Leica SP8 confocal microscopes, live-cell workstations, and micromanipulation systems.

TIANFU JINCHENG LAB

天府锦城实验室(前沿医学中心)Tianfu Jincheng Laboratory

不仅是实验室,更是连接基础科研与临床应用的桥梁。 Bridging basic research and clinical application.

SELECTED WORKS

代表性成果 Selected Publications

20+
SCI Papers

主持课题Grants & Projects

国家自然科学基金面上项目 National Natural Science Foundation (General Program)

金属多酚网络介导的卵母细胞-颗粒细胞体外组装策略通过糖代谢途径促进卵母细胞体外成熟的机制研究 (No. 82371730) Study on the Mechanism by Which Metal-Polyphenol Network-Mediated Oocyte-Granulosa Cell In Vitro Assembly Strategy Promotes Oocyte In Vitro Maturation Through Glycometabolic Pathways (No. 82371730)

四川省重点研发项目 Sichuan Key Research and Development Program

通过空间转录组技术与多模态分析探索胎儿脑发育障碍调控机制研究 (No. 24ZDYF0100) Study on the Regulatory Mechanisms of Fetal Brain Developmental Disorders Explored through Spatial Transcriptomics and Multimodal Analysis (No. 24ZDYF0100)

团队成员 Our Team

一支由博士后、临床医生及研究生组成的跨学科创新团队 An interdisciplinary innovation team comprising postdocs, clinicians, and graduate students.

博士后Postdoctoral Fellows

Member

魏万千Wanqian Wei

博士后Postdoc

博士毕业于中国科学院大学遗传学专业,主要从事生物信息学以及群体遗传学研究。 A Ph.D. graduate from the University of Chinese Academy of Sciences with a major in Genetics and bioinformatics.

Member

韦伟灯Weideng Wei

博士后Postdoc

博士毕业于四川大学华西口腔医学院,长期从事生物信息学、多模态AI以及精准医学交叉领域的研究工作。 A Ph.D. graduate from West China School of Stomatology, Sichuan University, with long-term research experience in bioinformatics, multimodal AI, and precision medicine.

Member

刘志强Zhiqiang Liu

博士后Postdoc

博士毕业于中国农业大学,专注于环境毒理学与生殖健康研究。 A Ph.D. graduate from China Agricultural University, specializing in environmental toxicology and reproductive health research.

博士研究生Ph.D. Students

Member

骆瑞杰Ruijie Luo

博士生Ph.D. Candidate

研究方向:卵母细胞质量控制。 Focus: Oocyte quality control mechanisms.

Member

何行思Xingsi He

博士生Ph.D. Candidate

硕士毕业于南京医科大学生殖医学与子代健康全国重点实验室,主要研究兴趣在于雌性生殖衰老。 Graduated with a master's degree from Nanjing Medical University, with a primary research interest in female reproductive aging.

硕士研究生Master Students

Member

戴怡琳Yilin Dai

硕士生Master Student

研究方向:硕士毕业于西南大学发育生物学专业,主要研究方向为器官发育。 Focus: Graduated with a master's degree in Developmental Biology from Southwest University, with a primary research focus on organ development.

Member

朱曼曼Manman Zhu

硕士生Master Student

研究方向:四川大学硕士研究生,参与卵巢早衰及宫腔粘连动物模型构建。 Focus: Sichuan University master's student, involved in the development of animal models for premature ovarian failure and intrauterine adhesions.

Member

江怡Yi Jiang

硕士生Master Student

研究方向:四川大学硕士研究生,专注于生殖健康研究,善于运用数据驱动的方式探索从群体公共卫生到个体临床医学的科学问题。 Focus: Sichuan University master's student, focusing on reproductive health research, skilled in using data-driven approaches to explore scientific questions from population public health to individual clinical medicine.

Member

张建军Jianjun Zhang

硕士生Master Student

研究方向:本科就读于上海交通大学医学院,有丰富的临床科研经验。 Focus: Completed undergraduate studies at Shanghai Jiao Tong University School of Medicine, with extensive clinical research experience.

往届成员Alumni

Member

朱三San Zhu

往届成员Alumni

毕业去向:复旦大学。 Current: Fudan university.

课题组新闻 Lab News

2025 Year

张曜耀教授在中国优生科学协会青年工作委员会换届会议暨2025年度学术交流大会做精彩报告 Prof. Yaoyao Zhang delivered a keynote speech at the 2025 Academic Conference of the China Eugenics Science Association Youth Committee

近日,中国优生科学协会青年工作委员会换届会议暨2025年度学术交流大会顺利召开。张曜耀教授受邀出席并做精彩学术报告,分享了课题组在生殖医学与衰老研究领域的最新进展。 Recently, the Re-election Meeting and 2025 Academic Conference of the Youth Working Committee of the China Eugenics Science Association was held. Prof. Yaoyao Zhang was invited to give a report, sharing the lab's latest progress in reproductive medicine and aging research.

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加入我们Join Us

长期招收博士后、科研助理及研究生
期待有志青年加入我们的团队
Openings for Postdocs, Research Assistants, and Graduate Students.
We welcome young talents to join us.

Email Address

yaoyaozhang@scu.edu.cn

Location

成都市高新区 成都前沿医学中心

Frontier Medical Center, Chengdu

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