AI & Reproductive Medicine

人工智能
与生殖医学前沿
AI
Frontiers in Reproductive Medicine

依托 华西第二医院天府锦城实验室 双重国家级平台
致力于生育力调控和生殖相关疾病研究
Based at the dual national platforms of West China Second Hospital and Tianfu Jincheng Laboratory.
Dedicated to decoding oocyte aging mechanisms and clinical translation.

张曜耀教授

张曜耀Yaoyao Zhang 教授Professor

博士生导师 博士后合作导师

PI简介Principal Investigator

教育部青年长江学者,四川大学华西第二医院生殖医学中心副主任,博士生导师,博士后合作导师。四川省高层次人才计划特聘专家,四川大学“双百人才计划”入选者,教育部“101计划”基础医学生殖系统学科编委,获四川省科技进步二等奖,四川省医学科技二等奖,全国首届“张丽珠”医学青年创新奖入选者,国家“互联网+”大学生创新创业大赛银奖指导教师。博士毕业于北京大学,师从乔杰院士,长期从事妇产科学及生殖医学临床、科研与教学工作。

近年来,以第一/通讯作者在 Molecular Cell, Nature Communications, Signal Transduction and Targeted Therapy (STTT), European Journal of Cancer 等国际重要学术期刊发表学术论文。研究成果被 NatureCellScience 等顶级期刊引用,已实现临床转化并获5项发明专利。作为副主编出版《如何保存生育力》,参编《生殖内分泌学》等专著,并参与编写5项重要临床指南及专家共识。受邀在欧洲生殖年会(ESHRE),美国生殖年会(ASRM),国际生育联盟大会(IFFS),亚太生殖年会(ASPIRE)、国际定量生物学大会、中华医学会生殖医学分会、中国医师协会生殖医学分会、中国细胞生物学会等国际国内学术大会做特邀报告。

通过跨学科交叉(生殖医学与发育生物学+生物信息学+人工智能)全链条布局,推动生育力保护全周期交叉学科创新研究及临床转化。目前课题组拥有成员10余人,包括副研究员,博后,博士生等,团队背景高度交叉互补,包括医学,生物学,计算机与人工智能等,人员梯队结构合理,拥有浓厚科研氛围及温馨的团队文化,为学生及青年人才发展提供最优质资源与孵化土壤。课题组基础研究场所位于天府锦城实验室,以建设国家实验室与国家重大科技基础设施集群为目标,与北京大学成都交叉研究院,国家精准医学产业创新中心等国内顶级科研院所紧密合作。

Young Changjiang Scholar (Ministry of Education), Deputy Director of the Reproductive Medicine Center at West China Second University Hospital, Sichuan University. He is a Doctoral Supervisor, Postdoctoral Supervisor, Distinguished Expert of the Sichuan High-Level Talent Program, and a selected member of Sichuan University's "Double Hundred Talents Plan". He also serves as an Editorial Board Member for the Ministry of Education's "101 Plan" (Reproductive System). He has received the Sichuan Science and Technology Progress Award (2nd Prize), the Sichuan Medical Science and Technology Award (2nd Prize), and the inaugural National "Zhang Lizhu" Medical Youth Innovation Award.

In recent years, he has published academic papers as the first or corresponding author in leading international journals such as Molecular Cell, Nature Communications, Signal Transduction and Targeted Therapy (STTT), and European Journal of Cancer. His research findings have been cited by top journals like Nature, Cell, and Science, and have been successfully translated into clinical practice, resulting in 5 invention patents. He served as Associate Editor for the monograph How to Preserve Fertility and co-edited works like Reproductive Endocrinology. Additionally, he participated in drafting 5 major clinical guidelines and expert consensuses.

Through an interdisciplinary approach combining Reproductive Medicine, Developmental Biology, Bioinformatics, and AI, the team promotes full-cycle innovation and clinical translation in fertility preservation. The research group currently consists of over 10 members, including Associate Research Fellows, Postdocs, and Ph.D. students, with diverse backgrounds in Medicine, Biology, Computer Science, and AI. The team boasts a reasonable hierarchy, a strong research atmosphere, and a warm culture, providing top-tier resources and an incubation ground for students and young talents.

四川省高层次人才计划特聘专家Distinguished Expert of Sichuan Province 四川大学“双百人才计划”SCU "Double Hundred Talents Plan" “101计划”基础医学生殖系统学科编委MOE "101 Plan" Editorial Board Member
INFRASTRUCTURE

科研平台 Research Facilities

依托华西二院天府锦城实验室双重国家级平台,实现临床-基础-转化的全链条闭环。 Full-chain closed loop from clinical samples to basic research.

WEST CHINA 2ND HOSPITAL

华西第二医院West China Second Hospital

国家妇产疾病临床医学研究中心,提供顶尖的临床资源支持。 National Clinical Research Center.

国家级临床中心National Clinical Center

依托国家妇产疾病临床医学研究中心,拥有全国领先的妇产科临床诊疗规模。 Leading the country in clinical diagnosis and treatment scale.

千万级生物样本库Massive Biobank

涵盖卵泡液、颗粒细胞、胚胎培养液等珍贵临床样本。 Standardized biobank covering follicular fluid, granulosa cells, etc.

临床转化试验基地Clinical Trial Base

拥有完善的GCP管理体系,支持开展前瞻性随机对照试验(RCT)。 Comprehensive GCP management system supporting prospective RCTs.

前沿组学技术平台Advanced Omics Platform

配备 10x Genomics 单细胞测序系统、空间转录组测序平台。 Equipped with 10x Genomics single-cell sequencing systems.

分子生物学中心Molecular Biology Center

支持基因编辑、蛋白互作、表观遗传修饰等深层次机制研究。 Supporting gene editing, protein interaction, and epigenetic studies.

超高分辨显微成像中心Imaging Center

拥有 Leica SP8 激光共聚焦显微镜、活细胞工作站。 Leica SP8 confocal microscopes, live-cell workstations.

TIANFU JINCHENG LAB

天府锦城实验室Tianfu Jincheng Laboratory

不仅是实验室,更是连接基础科研与临床应用的桥梁。 Bridging basic research and clinical application.

SELECTED WORKS

代表性成果 Selected Publications

20+
SCI Papers

主持课题Grants & Projects

国家自然科学基金面上项目 National Natural Science Foundation (General Program)

金属多酚网络介导的卵母细胞-颗粒细胞体外组装策略... (No. 82371730) Study on the Mechanism by Which Metal-Polyphenol Network... (No. 82371730)

四川省重点研发项目 Sichuan Key Research and Development Program

通过空间转录组技术与多模态分析探索胎儿脑发育障碍... (No. 24ZDYF0100) Study on the Regulatory Mechanisms of Fetal Brain... (No. 24ZDYF0100)

团队成员 Our Team

一支由博士后、临床医生及研究生组成的跨学科创新团队 An interdisciplinary innovation team comprising postdocs, clinicians, and graduate students.

博士后Postdoctoral Fellows Postdoc

Member

魏万千Wanqian Wei

博士后Postdoc

博士毕业于中国科学院大学遗传学专业,主要从事生物信息学以及群体遗传学研究。 A Ph.D. graduate from the University of Chinese Academy of Sciences with a major in Genetics and bioinformatics.

Member

韦伟灯Weideng Wei

博士后Postdoc

博士毕业于四川大学华西口腔医学院,长期从事生物信息学、多模态AI以及精准医学交叉领域的研究工作。 A Ph.D. graduate from West China School of Stomatology, Sichuan University, with long-term research experience in bioinformatics, multimodal AI, and precision medicine.

Member

刘志强Zhiqiang Liu

博士后Postdoc

博士毕业于中国农业大学,专注于环境毒理学与生殖健康研究。 A Ph.D. graduate from China Agricultural University, specializing in environmental toxicology and reproductive health research.

博士研究生Ph.D. Students Ph.D.

Member

骆瑞杰Ruijie Luo

博士生Ph.D. Candidate

硕士毕业于四川大学华西临床医学院,主要研究方向为女性生育力保护。 Focus: Oocyte quality control mechanisms.

Member

何行思Xingsi He

博士生Ph.D. Candidate

硕士毕业于南京医科大学生殖医学与子代健康全国重点实验室,主要研究兴趣在于雌性生殖衰老。 Graduated with a master's degree from Nanjing Medical University, with a primary research interest in female reproductive aging.

硕士研究生Master Students Master

Member

戴怡琳Yilin Dai

硕士生Master Student

研究方向:硕士毕业于西南大学发育生物学专业,主要研究方向为器官发育。 Focus: Graduated with a master's degree in Developmental Biology from Southwest University, with a primary research focus on organ development.

Member

朱曼曼Manman Zhu

硕士生Master Student

研究方向:四川大学硕士研究生,参与卵巢早衰及宫腔粘连动物模型构建。 Focus: Sichuan University master's student, involved in the development of animal models for premature ovarian failure and intrauterine adhesions.

Member

江怡Yi Jiang

硕士生Master Student

研究方向:四川大学硕士研究生,专注于生殖健康研究,善于运用数据驱动的方式探索从群体公共卫生到个体临床医学的科学问题。 Focus: Sichuan University master's student, focusing on reproductive health research, skilled in using data-driven approaches to explore scientific questions from population public health to individual clinical medicine.

Member

张建军Jianjun Zhang

硕士生Master Student

研究方向:本科就读于上海交通大学医学院,有丰富的临床科研经验。 Focus: Completed undergraduate studies at Shanghai Jiao Tong University School of Medicine, with extensive clinical research experience.

往届成员Alumni

Member

朱三San Zhu

往届成员Alumni

毕业去向:复旦大学 Current: Fudan University.

Member

陈晗笑Hanxiao Chen

往届成员Alumni

毕业去向:Utrecht University,Hubrecht Institute Current: Utrecht University,Hubrecht Institute

Member

郭伟杰Weijie Guo

往届成员Alumni

毕业去向:澳门大学 Current: University of Macau

Member

冯博Bo Feng

往届成员Alumni

毕业去向:四川大学华西第二医院 Current: West China Second Hospital of Sichuan University

Member

刘家伶Jialing Liu

往届成员Alumni

毕业去向:中山大学医学院 Current: Sun Yat-sen University School of Medicine

课题组新闻 Lab News

2025 Year

张曜耀教授受邀参加“2025寒地龙医‘人工智能+医药’多学科交叉论坛” Prof. Yaoyao Zhang participated in the AI + Medicine Interdisciplinary Forum.

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2025 Year

张曜耀教授在中国医师协会生殖医学专业委员会第十一届生殖医学学术大会上宣读倡议书 Prof. Zhang read the proposal at the 11th Reproductive Medicine Congress of CMDA

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2025 Year

张曜耀教授在2025年第三届全国发育与疾病学术会议中作精彩报告 Prof. Zhang delivered a report at the 3rd National Development & Disease Conference

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2025 Year

张曜耀教授在2025中国抗癌协会生育力保护大会上作精彩报告 Prof. Zhang delivered a report at the 2025 CACA Fertility Preservation Congress

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2025 Year

张曜耀教授在中国优生科学协会青年工作委员会2025年度大会做精彩报告 Prof. Yaoyao Zhang delivered a keynote speech at the 2025 Academic Conference.

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2024 Year

张曜耀教授在第十六届全国儿童青少年健康学术会议上作精彩报告 Prof. Zhang delivered a report at the 16th National Child & Adolescent Health Conference

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2024 Year

张曜耀教授在定量生物学2024大会上作精彩报告 Prof. Zhang delivered a report at Quantitative Biology 2024

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2024 Year

张曜耀教授在西湖临床多组学研讨会中作精彩报告 Prof. Zhang delivered a report at the West Lake Clinical Multi-omics Symposium

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2024 Year

张曜耀教授在第二届发育与疾病研讨会中作精彩报告 Prof. Zhang delivered a report at the 2nd Development & Disease Symposium

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2023 Year

张曜耀教授在第五届世界生殖生物学大会(WCRB)上作精彩报告 Prof. Zhang delivered a report at the 5th World Congress of Reproductive Biology

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2023 Year

张曜耀教授在 ASRM 2023 大会上作精彩报告 Prof. Zhang delivered a report at the ASRM 2023 Scientific Congress & Expo

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2023 Year

张曜耀教授在 ASPIRE 2023 会议上作精彩报告 Prof. Zhang delivered a report at the 12th ASPIRE Congress (2023)

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