张曜耀Yaoyao Zhang 教授Professor
博士生导师
博士后合作导师
依托 华西第二医院 与 天府锦城实验室 双重国家级平台
致力于生育力调控和生殖相关疾病研究
Based at the dual national platforms of West China Second Hospital and Tianfu Jincheng Laboratory.
Dedicated to decoding oocyte aging mechanisms and clinical translation.
结合临床痛点，聚焦三大前沿领域 Focusing on three cutting-edge fields to address clinical challenges
利用单细胞多组学技术，解析卵母细胞的激活、发育、成熟等关键生物学事件。 Unraveling mitochondrial metabolism and aneuploidy mechanisms in age-related oocyte quality decline.
利用人工智能前沿技术AI进行疾病（如宫颈癌、内膜异位症）风险分层的临床应用。 Developing novel ovarian protective drugs and cryopreservation techniques against chemotherapy damage.
针对临床常见妇科疾病和生殖相关疾病造成的女性不育进行生育力保存。 Fertility preservation is carried out for female infertility caused by common gynecological diseases and reproductive-related diseases in clinical practice.
依托华西二院与天府锦城实验室双重国家级平台，实现临床-基础-转化的全链条闭环。 Full-chain closed loop from clinical samples to basic research.
国家妇产疾病临床医学研究中心，提供顶尖的临床资源支持。 National Clinical Research Center.
依托国家妇产疾病临床医学研究中心，拥有全国领先的妇产科临床诊疗规模。 Leading the country in clinical diagnosis and treatment scale.
涵盖卵泡液、颗粒细胞、胚胎培养液等珍贵临床样本。 Standardized biobank covering follicular fluid, granulosa cells, etc.
拥有完善的GCP管理体系，支持开展前瞻性随机对照试验（RCT）。 Comprehensive GCP management system supporting prospective RCTs.
配备 10x Genomics 单细胞测序系统、空间转录组测序平台。 Equipped with 10x Genomics single-cell sequencing systems.
支持基因编辑、蛋白互作、表观遗传修饰等深层次机制研究。 Supporting gene editing, protein interaction, and epigenetic studies.
拥有 Leica SP8 激光共聚焦显微镜、活细胞工作站。 Leica SP8 confocal microscopes, live-cell workstations.
不仅是实验室，更是连接基础科研与临床应用的桥梁。 Bridging basic research and clinical application.
国家自然科学基金面上项目 National Natural Science Foundation (General Program)
金属多酚网络介导的卵母细胞-颗粒细胞体外组装策略... (No. 82371730) Study on the Mechanism by Which Metal-Polyphenol Network... (No. 82371730)
四川省重点研发项目 Sichuan Key Research and Development Program
通过空间转录组技术与多模态分析探索胎儿脑发育障碍... (No. 24ZDYF0100) Study on the Regulatory Mechanisms of Fetal Brain... (No. 24ZDYF0100)
一支由博士后、临床医生及研究生组成的跨学科创新团队 An interdisciplinary innovation team comprising postdocs, clinicians, and graduate students.
博士后Postdoc
博士毕业于中国科学院大学遗传学专业，主要从事生物信息学以及群体遗传学研究。 A Ph.D. graduate from the University of Chinese Academy of Sciences with a major in Genetics and bioinformatics.
博士后Postdoc
博士毕业于四川大学华西口腔医学院，长期从事生物信息学、多模态AI以及精准医学交叉领域的研究工作。 A Ph.D. graduate from West China School of Stomatology, Sichuan University, with long-term research experience in bioinformatics, multimodal AI, and precision medicine.
博士后Postdoc
博士毕业于东北农业大学发育生物学专业，博士课题聚焦猪卵母细胞成熟的研究。熟练掌握小鼠等哺乳动物手术操作，胚胎显微操作，以及分子及细胞实验等。 Ph.D. in Developmental Biology, Northeast Agricultural University. Doctoral thesis: study of porcine oocyte maturation. Skills: mammalian surgery (e.g., mice), embryo micromanipulation, molecular and cellular experiments.
博士后Postdoc
博士毕业于中国农业大学，专注于环境毒理学与生殖健康研究。 A Ph.D. graduate from China Agricultural University, specializing in environmental toxicology and reproductive health research.
博士生Ph.D. Candidate
硕士毕业于四川大学华西临床医学院，主要研究方向为女性生育力保护。 Focus: Oocyte quality control mechanisms.
博士生Ph.D. Candidate
本科与硕士均就读于临床医学专业，具备扎实的医学基础与系统的临床思维。 Earned both Bachelor's and Master's degrees in Clinical Medicine, with a strong grounding in basic medical sciences and systematic clinical thinking.
博士生Ph.D. Candidate
硕士毕业于四川大学华西医学院妇产科学，从事卵巢癌干细胞代谢重编程相关研究。 Master's degree in Obstetrics and Gynecology from West China School of Medicine, Sichuan University. Research focus: metabolic reprogramming in ovarian cancer stem cells.
博士生Ph.D. Candidate
硕士毕业于四川大学华西临床医学院妇产科学，具备扎实临床科研与文献分析能力。 Master's graduate in Obstetrics and Gynecology from West China School of Medicine, Sichuan University, with strong capabilities in clinical research and literature review.
博士生Ph.D. Candidate
硕士毕业于南京医科大学生殖医学与子代健康全国重点实验室，主要研究兴趣在于雌性生殖衰老。 Graduated with a master's degree from Nanjing Medical University, with a primary research interest in female reproductive aging.
硕士生Master Student
硕士毕业于香港中文大学（深圳）bioinformatics 专业。曾作为负责人参与国家级大创等多项科研项目，研究涵盖厌氧消化体系、酶动力学参数预测及miRNA-mRNA调控网络分析。 She holds a Master's in Bioinformatics from CUHK‑Shenzhen and has led several projects (including a national innovation program) on anaerobic digestion, enzyme kinetics, and miRNA‑mRNA regulatory networks.
硕士生Master Student
硕士毕业于香港中文大学（深圳）bioinformatics 专业。有生物信息实习与酶工程、基因挖掘、作物 QTL 定位等科研项目经验，熟练使用Python、R 完成组学分析。 She holds a Master's in Bioinformatics from CUHK‑Shenzhen and has experience in bioinformatics internships and research projects in enzyme engineering, gene mining, and crop QTL mapping, and is proficient in Python and R for omics data analysis.
硕士生Master Student
硕士毕业于香港中文大学（深圳）bioinformatics 专业，研究涵盖犬猫细小病毒分型与新发亚型毒株监测，基于多模态机器学习模型的药物毒性预测方法与优化。 She holds a Master’s in Bioinformatics from CUHK‑Shenzhen, with research on parvovirus typing, emerging subtype surveillance, and drug toxicity prediction using multimodal machine learning models.
硕士生Master Student
硕士毕业于成都中医药大学中药学专业， 从事中药化学有效成分与质量标准研究方向，熟悉中药化学成分的提取、分离、纯化、检验工作，并在心血管领域做过相关的药理研究。 She holds a Master’s in Chinese Materia Medica from Chengdu University of TCM, with research on active ingredients and quality standards, expertise in extraction, isolation, purification, and analysis of TCM components, and experience in cardiovascular pharmacology.
硕士生Master Student
研究方向：四川大学硕士研究生，专注于生殖健康研究，善于运用数据驱动的方式探索从群体公共卫生到个体临床医学的科学问题。 Focus: Sichuan University master's student, focusing on reproductive health research, skilled in using data-driven approaches to explore scientific questions from population public health to individual clinical medicine.
硕士生Master Student
研究方向：本科就读于上海交通大学医学院，有丰富的临床科研经验。 Focus: Completed undergraduate studies at Shanghai Jiao Tong University School of Medicine, with extensive clinical research experience.
交换生Exchange Students
就读于加拿大英属哥伦比亚大学药理学专业，主要参与卵巢相关科研项目。 Currently enrolled in the Pharmacology program at the University of British Columbia (UBC), with a primary research focus on ovarian-related topics.
交换生Exchange Students
现就读于加拿大英属哥伦比亚大学认知系统专业，参与卵巢衰老机制相关科研项目。 Currently studying Cognitive Systems at the University of British Columbia (UBC), Canada, with active involvement in a research project investigating the molecular mechanisms underlying ovarian aging.
往届成员Alumni
毕业去向：复旦大学 Current: Fudan University.
往届成员Alumni
毕业去向：/ Current: /
往届成员Alumni
毕业去向：/ Current:/
往届成员Alumni
毕业去向：Utrecht University，Hubrecht Institute Current: Utrecht University，Hubrecht Institute
往届成员Alumni
毕业去向：澳门大学 Current: University of Macau
往届成员Alumni
毕业去向：四川大学华西第二医院 Current: West China Second Hospital of Sichuan University
往届成员Alumni
毕业去向：中山大学医学院 Current: Sun Yat-sen University School of Medicine
长期招收 博士后、研究生以及科研助理
期待有志青年加入我们的团队
Openings for Postdocs, Research Assistants, and Graduate Students.
We welcome young talents to join us.
Supervisor Profile
四川大学华西临床医学院导师主页 WCH SCU Supervisor ProfileLab Expert Profile
天府锦城实验室青年专家主页 Tianfu Jincheng Lab Young Expert
